Boris Johnson and the deputy chief medical officer Jonathan Van Tam this evening revealed their intense emotions after being told a coronavirus vaccine developed by Pfizer can now start to be rolled out across the UK.
Mr Johnson described it as a ‘huge moment’ and also ‘a very moving thing’ while Mr Van Tam admitted he was ‘quite emotional this morning’ after he got the news that the Medicines and Healthcare Products Regulatory Agency (MHRA) had given the jab the green light.
However, speaking on the day that his new Covid-19 tier system was implemented across England, Mr Johnson warned that the ‘worst thing now would be to think that this is the moment when we can relax our guard’.
The Prime Minister said it would be wrong to think it is ‘game over in the fight against Covid’ and ‘this is not the end’ as he urged people to stick to the new rules.
The Joint Committee on Vaccination and Immunisation (JCVI) today published its priority list for which groups will receive the jab first, with elderly care home residents in the top category.
But there are growing fears that care home residents could be made to wait for the vaccine because of the logistical challenges of moving around medicine which must be stored long term at -70C.
Sir Simon Stevens, chief executive of NHS England, said as he stood alongside Mr Johnson and Mr Van Tam at a Downing Street press conference that the vaccine rollout will begin next week at 50 ‘hospital hubs’ in England.
Mr Johnson then admitted that while the Government wants to get the vaccine into care homes ‘as fast as we possibly can’ there are ‘difficulties’ associated with that process.
Lorries loaded with the first batches of Pfizer/BioNTech’s coronavirus vaccine are already on their way to Britain after the breakthrough jab sealed approval from the UK’s medical regulator.
Thousands of doses of the vaccine were shipped from Pfizer’s factories in Belgium this morning within hours of it being given the green light by the MHRA, making Britain the first country in the world to have a clinically authorised Covid-19 jab. The doses could reach Britain as soon as tomorrow.
Speaking in Number 10 this evening, Mr Johnson said: ’This is a huge moment and… it is also a very moving thing.
‘I am really lost in admiration for science and the ability of scientists to solve human problems in the way that they can.
Boris Johnson today described the decision by regulators to give the green light to Pfizer’s coronavirus vaccine as a ‘huge moment’ and also ‘a very moving thing’
Deputy chief medical officer Jonathan Van Tam echoed a similar sentiment as he said he was ’emotional’ after he got the news this morning
‘This is not easy. Bear in mind we have got a vaccine now for Covid that really, really works, there is no question that it works, but we haven’t got a vaccine for Sars, for Mers, for HIV. There is a huge, huge, fantastic effort that has gone into this.
‘And when you consider the damage that this virus has done to human life across the planet, the economic damage, the social damage to say nothing of the cost in life and suffering, it is a fantastic moment.
‘But to repeat the key message, the worst thing now would be to think that this is the moment when we can relax our guard and think that it is game over in the fight against Covid. This is not. This is not the end.’
Professor Van Tam echoed a similar sentiment as he said: ’I don’t mind telling you, I am not saying it for effect, the office will ell you it is true, that I was quite emotional this morning when I heard June Raine, Sir Munir Pirmohamed and Wei Shen Lim lay out how they had got very meticulously to their conclusions about the Pfizer vaccine.
‘And what a momentous journey and international effort it has been. Discovery by two scientists who originally lived in Turkey, development by a German biotech company, involvement of a massive US pharmaceutical giant and then involvement of our own UK MHRA to bring home the goods in terms of the UK. What a fantastic journey.’
Some 800,000 doses of Pfizer’s vaccine — which requires two doses being taken 21 days apart in order to be fully effective — will be made available from next week.
The UK has pre-ordered 40million doses in total, with 10million due by the end of 2020 and the rest next year.
But there is growing confusion about which groups will get the first doses. The JCVI published its Covid-19 priority list this morning, advising that care home residents and the staff who treat them should be the first in line to be inoculated.
However, officials warned they couldn’t promise care homes would get the vaccine before everyone else, admitting ‘whether or not that is actually doable depends on deployment and implementation’.
Pfizer/BioNTech’s jab blocks 95 per cent of Covid-19 infections, according to trial results that shows it works just as well among over-65s, who are most at risk of the disease.
But transporting and storing the vaccine poses logistical challenges because it must be kept in long-term storage at -70C. To keep doses of the jab at this ultra-low temperature, they need to be packaged with dry ice and placed in a special transport box the size of a suitcase which hold 5,000 doses.
These containers can prevent the vaccines from spoiling for 10 days if they remain unopened.
Once the batches arrive at vaccination hubs, they can be stored in standard medical fridges at between 2C and 8C for up to five days. Or they can be kept in their shipping boxes for up to 30 days if the containers are topped up with dry ice at least once a week.
Fifty NHS hospitals in England are already equipped with super-cold freezers that can keep the vaccine at -70C, meaning healthcare staff could be inoculated first. However, there is a potentially major sticking point for roll out to care homes because BioNTech says that the vaccine can only be kept at between 2C and 8C for six hours in transit without going off.
Because the Pfizer suitcases hold 5,000 vaccine doses, smaller quantities would have to be removed from the dry ice suitcases for transport to care homes. But once they are in transit the doses could perish after six hours.
Sir Simon said at the press conference that the vaccine ‘also comes in packs of 975 people’s doses’ which would be easier to move around but would still be too big to be stored at a single GP practice.
Mr Johnson conceded that rolling the vaccine out to care homes will be difficult as he said: ‘The issue is, of course we want to get it into care homes to protect the most vulnerable as fast as we possibly can. The Joint Committee on Vaccination and Immunisation has rightly said that care home residents must be a priority.
‘The difficulty is in distributing the cases to care homes. Each case has 975 vaccines in it and obviously you want to avoid wastage and the difficulty is that the MHRA has not yet authorised the people who would be transporting the vaccine to the care homes to be able to effect the division themselves.’
Welsh Health Minister Vaughan Gething had earlier said the logistical issues meant ‘in practical terms at this stage that we cannot deliver this vaccine to care homes’.
The MHRA moved with unprecedented speed to approve the jab within just a week of receiving the final data from Pfizer’s phase three trials. The watchdog had been conducting a ‘rolling review’ of the vaccine, scrutinising data from its studies in real-time. MHRA chief executive Dr June Raine insisted that despite the rapid approval, the vaccine had been assessed ‘with meticulous care’ and ‘no corners had been cut’.
The announcement comes on the day England emerged from its second national lockdown and came as figures showed Covid cases and deaths are continuing to fall, with another 648 fatalities and 16,170 cases as the second wave dies down.
In other vaccine developments on the back of Pfizer’s approval:
- Organised criminal gangs may capitalise on the approval of the new Covid vaccine by stealing supplies to sell on or peddling fake doses, Interpol warned;
- Comparisons between Pfizer’s vaccine and the Thalidomide scandal are ‘insulting’, a charity warned after the birth defect-causing drug began trending on Twitter in the wake of Britain approving the jab;
- Supermarket giant Iceland’s boss told No10 it ‘stands ready’ to help the UK deliver the Covid vaccine, saying the firm’s ‘cold chain expertise’ may be helpful in local distribution of the jab;
- Teachers, soldiers, and bus drivers could be first in line for a Covid vaccine once all over-50s and ‘at-risk’ Britons are protected, JCVI guidance suggests;
- Matt Hancock claims Brexit helped Britain become first country in the world to approve a Covid vaccine ‘because European regulators were moving too slowly’;
- The Health Secretary says he’ll take the Covid vaccine live on TV to show it’s safe in attempt to quell any anxiety;
- Britain may still need a circuit breaker lockdown in January or February – despite roll-out of Pfizer’s 95 per cent effective jab beginning next week, top scientist warns;
- The MHRA was so keen to approve Pfizer’s Covid vaccine that it responded to emails within ten minutes, according to Pfizer’s vice president for medical and scientific affairs;
- Britons given Pfizer’s Covid vaccine will get partial immunity within 12 days of the first dose, MHRA regulators believe;
- NHS workers in Leicester have received an email confirming Leicester racecourse will be transformed into a vaccination hub ‘as soon as the government says go’.
A lorry leaves Pfizer’s manufacturing plant in Puurs, Belgium, this morning after the American firm’s Covid-19 vaccine was approved in the UK. It’s not clear if the lorry pictured was transporting the jabs
About 800,000 doses of the Pfizer’s vaccine — enough to vaccinate 400,000 people because it is administered in two shots — will be made available in Britain ‘from next week’. It’s not clear if the lorry pictured was transporting the jabs
This handout photo taken in October and provided by Pfizer shows part of a ‘freezer farm,’ a football field-sized facility for storing finished COVID-19 vaccines, in Puurs, Belgium
The vaccine needs to be kept at -70C. To keep doses of the jab at this ultra-low temperature, they need to be packaged with dry ice and placed in a special thermal transport box (shown)
Health Secretary Matt Hancock, making a statement to the Commons, told MPs: ‘Today marks a new chapter in our fight against this virus. ‘Ever since the pandemic hit our shores almost a year ago we have known a vaccine would be critical to set us free.’
WHICH HOSPITALS WILL GET THE VACCINE FIRST?
- Blackpool Teaching Hospitals
- Brighton and Sussex University Hospitals
- Cambridge University Hospitals
- Chesterfield Royal Hospital
- Countess of Chester Hospital
- Croydon University Hospital
- Dartford and Gravesham Hospitals
- Dorset County Hospitals
- East and North Hertfordshire Hospitals
- East Kent Hospitals
- East Suffolk and North Essex Hospitals
- Frimley Health NHS Foundation Trust
- Gloucestershire Hospitals
- Great Western Hospitals
- Guys & St Thomas NHS Trust
- James Paget University Hospitals
- Kings College Hospital
- Princess Royal University Hospital, Kings
- Lancashire Teaching Hospital
- Leeds Teaching Hospital
- Leicester Partnership NHS Trust
- Liverpool University Hospitals
- Medway NHS Foundation Trust
- Mid and South Essex Hospitals
- Milton Keynes University Hospital
- Norfolk and Norwich University Hospital
- Northampton General Hospital
- North Bristol NHS Foundation Trust
- North West Anglia Foundation Trust
- Nottingham University Hospitals
- Oxford Health NHS Foundation Trust
- Portsmouth Hospital University
- Royal Cornwall Hospitals
- Royal Free London NHS Foundation Trust
- Salford Royal NHS Foundation Trust
- Sheffield Teaching Hospitals
- Sherwood Forest Hospitals
- Shrewsbury and Telford NHS Trust
- Stockport NHS Foundation Trust
- St George’s University Hospitals
- The Newcastle Upon Type Hospitals
- University College Hospitals
- University Hospitals Birmingham
- University Hospitals Coventry and Warwickshire
- University Hospitals Derby Burton
- University Hospitals of North Midlands
- University Hospitals Plymouth
- United Lincolnshire Hospitals
- Walsall Healthcare
- West Hertfordshire Hospitals
- Wirral University Teaching Hospital
- Worcestershire Acute Hospitals
- Yeovil District Hospital
UK REGULATOR INSISTS ‘NO CORNERS WERE CUT’ IN APPROVING THE VACCINE
Britain’s Medicines and Healthcare Products Regulatory Agency (MHRA) moved with unprecedented speed to approve the jab within just a week of receiving the final data from Pfizer’s phase three trials. The watchdog had been conducting a ‘rolling review’ of the vaccine, scrutinising data from its studies in real-time.
MHRA chief executive Dr June Raine insisted that despite the rapid approval, the vaccine had been assessed with ‘with meticulous care’.
She told the Downing Street press conference: ‘That doesn’t mean that any corners have been cut, none at all.’
Dr Raine said experts had worked ’round the clock, carefully, methodically poring over tables and analyses and graphs on every single piece of data’.
More than 1,000 pages of data had been examined, she said.
She said: ‘The way of working in a rolling review ensures that our teams of clinicians and scientists are working in parallel to complete all of the work according to strict guidelines on safety, effectiveness and quality.’
The vaccine had ‘only been approved because those strict tests have been done and complied with’.
Dr Raine said: ‘If you are climbing a mountain, you prepare and prepare. We started that in June.
‘By the time the interim results became available on November 10 we were at base camp and then when we got the final analysis we were ready for that last sprint that takes us to today.
‘That is the exemplary nature of the work that has been done and the public deserve nothing less.’
Ben Osborn, Pfizer’s UK country manager, said that delivery of the vaccine was happening ‘right now’.
He said: ‘As you probably heard from the Secretary of State, Matt Hancock, earlier this morning, the delivery schedule has already been put in place.
‘We are delivering right now as we speak from Belgium into the UK – that process has already begun.
‘We anticipate that we will be providing some 800,000 doses or so in the coming days, ready for deployment next week by the NHS.’
He said the pharmaceutical company was not ‘giving an absolute figure’ on the total numbers which would be delivered to the UK this year.
Mr Osborn added: ‘You’ll understand this is a significant challenge to deliver. But we will be in a position to deliver millions of doses in the weeks ahead.
‘That is part of a bigger scale-up, which will essentially allow the UK to have 40million doses of the Pfizer/BioNTech vaccine.’
Sean Marett, chief commercial officer at BioNTech, said the first consignment of its newly-approved vaccine could reach Britain as soon as tomorrow.
He told BBC Radio 4’s World At One programme: ‘We’re packing them now as we speak and getting ready for shipping. What we can definitely say is it will arrive, the first consignment, in the next few days and that could be as early as tomorrow or it could be a few days later, but the UK will be the first country in the world to be receiving vaccine for administration to its population.
‘We will probably be shipping several consignments to the UK over the next few weeks and it might be that the numbers vary on size of packaging that we put together in a lorry and then ship, so the UK has a good number of vaccines coming to it in December.’
Before the first batch of doses were sent to Britain, batches were checked at a central depot to ensure their quality. The vaccine will then be unloaded and moved to storage freezers where it will undergo an additional temperature check.
Public Health England (PHE) will process orders placed by the NHS for next day delivery to hospital hubs around the UK. Defrosting the vaccine for use takes several hours and then extra time is needed to prepare the vaccine for administering as doses.
Health Secretary Matt Hancock — who admitted he was unsure how many people need to be vaccinated before restrictions can be lifted — told the Commons the first batch of the vaccine was completed this morning.
He said the rollout of the vaccine will be ‘one of the biggest civilian logistical efforts that we’ve faced as a nation’.
Mr Hancock told MPs: ‘It will be difficult. There will be challenges and complications, but I know that the NHS is equal to the task.’
He added: ‘We will deliver according to clinical prioritisation and operational necessity because of the need to hold the vaccine at minus-70 – it makes this vaccine particularly challenging to deploy.’
Mr Hancock said the roll out of the jab represented the start of a ‘new chapter in our fight against this virus’.
He said: ‘Ever since the pandemic hit our shores almost a year ago we have known a vaccine would be critical to set us free. It’s no longer if there’s going to be a vaccine, it’s when.
‘In our battle against the virus, help is on its way. Today is a triumph for all those who believe in science, a triumph for ingenuity, a triumph for humanity.’
Professor Wei Shen Lim, chair of the JCVI, told a Downing Street press conference this morning: ‘The advice is aimed at maximising the benefit from vaccines and therefore it is aimed at the most vulnerable people, which are people in care homes.’
He added: ‘Whether or not the vaccine can be delivered to care homes is a valid point and there will be some flexibility [with the priority list]. Every effort should be made to supply and offer the vaccine to care home residents. Whether that’s doable is dependent on deployment and implementation.’
At Prime Minister’s Questions at lunchtime, Mr Johnson admitted there would be ‘logistical’ issues in trying to get all care homes immunised first after being quizzed by Sir Keir Starmer.
The Labour leader asked: ‘What plans has he put in place to address these particular problems of getting the vaccine safely and quickly into care homes, given the practical difficulties of doing so and the anxiety that those in care homes will have about getting it quickly?’
Mr Johnson said: ‘It does need to be kept at -70C, as I think the House understands, so there are logistical challenges to be overcome to get vulnerable people the access to the vaccine that they need.
‘We are working on it with all four devolved administrations in order to ensure that the NHS across the country is able – and it’s the NHS that will be in the lead – to distribute it as fast and as sensibly as possible to the most vulnerable groups.’
Welsh Health Minister Mr Gething raised more doubts that care homes would be inoculated first this morning when asked about the vaccine’s deployment.
He said the Government in Wales had been exploring ‘suitable options for initial deployment of this vaccine’, but ‘in practical terms at this stage that we cannot deliver this vaccine to care homes’.
But Sean Marett, who is chief commercial officer at BioNTech and responsible for distribution, took issue with UK officials’ claims the Covid-19 vaccine would be a logistical nightmare to get to care homes.
He said: ‘We have stability studies now really supporting the evidence for being able to transport up to six hours at two to eight degrees, so you can really take vials from the vaccination centre – one of the large ones – put them in a bag at two to 8C and take them to the care homes where they can be administered directly to the patients.’
He added: ‘If you store the vaccine in a fridge, you can store it for up to five days. If you want to take some of those vials out of the fridge containing the vaccine, and ship them to a local care home, then you have to do that within six hours at two to eight degrees.’
Mr Marett said one option is pure storage where you take the vaccine out and use it for the patient, and the other is to put it in a van, and deliver those vaccines to a care home.
‘There you need to deliver within six hours, at two to eight and use the vaccine thereafter,’ he said.
Chancellor Rishi Sunak, pictured today at Hamleys toy shop in central London as it reopened after lockdown, said he hoped the vaccine roll-out would boost consumer confidence
Mr Sunak said: ‘It’s a moment of great hope and opportunity, but there’s still work to do,’ as the first vaccines began making their way to the UK today
Chancellor Rishi Sunak welcomed the news as ‘another positive step on our journey to beat this thing’ and paid ‘enormous tribute to everyone involved’.
He said: ‘It’s a moment of great hope and opportunity, but there’s still work to do. We’ve got to get the vaccines, we got to roll them out. All that work is ongoing, people should feel reassured about that.’
Mr Sunak said he hoped the vaccine roll-out would boost consumer confidence, which was ‘critical’ for Britain’s economic recovery. ‘Hopefully, this is the start of a march back,’ he added.
Today’s announcement makes the UK the first country in the world to have a clinically authorised Covid-19 vaccine, which Professor Sir Munir Pirmohamed, of the Commission on Human Medicines advisory panel, described as an ‘historic moment’.
He told the press conference: ‘We are in the midst of a once-in-a-century pandemic and I think this is a historic moment. The UK is now one step closer to providing a safe and effective vaccine to help in the fight against Covid-19, a virus that has affected each and every one of us in some way. This will help to save lives.’
Britain may still need a circuit breaker lockdown in January or February, top scientist warns
Britain may still need a circuit-breaker lockdown in late winter despite the promising vaccine news today, a top scientist warned.
Liam Smeeth, professor of clinical epidemiology at the London School of Hygiene and Tropical Medicine, said although some vulnerable groups will be inoculated by this year, mass vaccination won’t happen for months.
He warned this gives Covid-19 weeks to proliferate during the deep winter months, when viruses spread more easily as people stay indoors more.
Professor Smeeth said: ‘The continued progress on vaccines is fantastic news.
‘A route towards a much better situation in the UK is becoming clear.
‘But a further circuit-breaker in January or possibly February is likely to be needed.’
Mr Hancock also hailed the news, saying: ‘We can see the dawn in the distance but we have to get through to the morning.’ Mass-vaccination is seen as the only way to put an end to the perpetual opening up and closing down of society through draconian lockdowns, which have had devastating consequences on the economy and wider health.
Regulators today claimed Pfizer’s Covid vaccine offers ‘partial immunity’ within just twelve days of getting the first dose.
Professor Sir Munir Pirmohamed, chair of Commission on Human Medicine expert working group — which advises ministers on medicinal products, said that some protection occurs after receiving the first of the two-shot vaccine.
It offers a glimmer of hope that the roll-out of the vaccine beginning next week may have an effect before Christmas.
In a Downing Street press conference today, he revealed people ‘will be immune seven days after the second dose’ of the vaccine, which is taken roughly 21 days later.
Scientists remain unsure as to how long immunity against Covid lasts for, with fears protection may only be short-lived. But in-depth studies suggest that the majority of survivors will be able to fight off the disease within at least six months.
Some experts have claimed people may need to be vaccinated against the disease every winter, like the flu.
MHRA chief executive Dr June Raine told the Downing Street briefing today that, despite the jab being approved in record time, the process had been done with ‘meticulous care’, adding: ’That doesn’t mean that any corners have been cut, none at all.’
Dr Raine said experts had worked ’round the clock, carefully, methodically poring over tables and analyses and graphs on every single piece of data’.
An employee at the Pfizer laboratories where they conduct research and development. Vials of the lifesaving jab are seen as an employee works on the Covid-19 vaccine
Volunteers given Pfizer’s jab reveal how they had headaches and left them ‘aching all over’
Glenn Geshields (left), 44, said he was proud to have taken part. Carrie (right), 45, also from the US, was also involved in Pfizer’s vaccine trial
Volunteers on the Pfizer vaccine trial have compared the jab’s side effects to a ‘severe hangover’ and said it left them with headaches, fever and muscle aches similar to the flu vaccine.
One 45-year-old volunteer said the first dose left her suffering side effects similar to the flu jab but that her symptoms were ‘more severe’ after her second jab.
Another volunteer, 44-year-old Glenn Deshields, said Pfizer’s vaccine made him feel like he had a ‘severe hangover’ but that symptoms quickly cleared up.
More than 43,500 people in six countries took part in the phase three trials by the pharmaceutical giant in the hunt for an effective Covid-19 vaccine.
Bryan, 42, an engineer from Georgia, believes he was one of the individuals that did not receive the vaccine.
He felt no immune response to the jabs, he said, and after having two shots he contracted Covid-19 after his daughter caught it last month. They have both since recovered.
Matt Hancock claims BREXIT helped Britain become first country in the world to approve a Covid vaccine
Health Secretary Matt Hancock said Brexit has helped the UK become the first country in the world to have a clinically authorised vaccine.
He told Times Radio: ‘And the reason we’ve been able to move this fast, and the UK is the first country in the world to have a clinically authorised vaccine, the reason is twofold.
‘Firstly, because the MRHA has done a great job of working with the company to look at that data as it’s come through and do things in parallel, rather than one after the other as they normally would, that’s the first reason.
‘The second reason is because, whilst until earlier this year we were in the European Medicines Agency (EMA), because of Brexit we’ve been able to make a decision to do this based on the UK regulator, a world-class regulator, and not go at the pace of the Europeans, who are moving a little bit more slowly.
‘We do all the same safety checks and the same processes, but we have been able to speed up how they’re done because of Brexit.’
Hancock says he’ll take a vaccine live on air to show it’s safe
ITV’s Good Morning Britain presenter Piers Morgan made the suggestion before Mr Hancock said: ‘Yeah, I’ll take it with you, Piers’
Health Secretary Matt Hancock has offered to get vaccinated live on television to help convince people it is safe.
ITV’s Good Morning Britain presenter Piers Morgan made the suggestion before Mr Hancock said: ‘Yeah, I’ll take it with you, Piers’.
Morgan said: ‘I’ll come to where you are anytime next week if we can do this. Let’s do it together, live on air. It would be powerful, it would send the right message.’
Mr Hancock said: ‘Well, we’d have to get that approved because, of course, there is a prioritisation according to clinical need and, thankfully, as a healthy, middle-aged man, you’re not at the top of the prioritisation.
‘But if we can get that approved and if people think that’s reasonable then I’m up for doing that because once the MHRA has approved a vaccine, they only do that if it is safe.
‘And so, if that can help anybody else, persuade anybody else that they should take the vaccine then I think it’s worth it.’
Boris Johnson’s press secretary suggested the Prime Minister could be prepared to be vaccinated against coronavirus live on TV – but only if it did not prevent someone more in need of a jab from receiving one.
Allegra Stratton told reporters: ‘We all know the character of the Prime Minister, I don’t think it would be something that he would rule out.
‘But what we also know is that he wouldn’t want to take a jab that should be for somebody who is extremely vulnerable, clinically vulnerable, and who should be getting it before him.’
More than 1,000 pages of data had been examined, she said. Dr Raine added: ‘We have carried out a rigorous scientific assessment of all the available evidence of quality, safety and effectiveness. The public’s safety has always been at the forefront of our minds – safety is our watchword.
‘I’m really pleased to say that the UK is now one step closer to providing a safe and effective vaccine to help in the fight against Covid-19 – a virus that has affected each and every one of us in some way – and in helping to save lives.’We are globally recognised for requiring high standards of safety, quality and effectiveness for any vaccine.
‘Our expert scientists and clinicians worked tirelessly, around the clock, carefully, scientifically, robustly and rigorously poring over hundreds of pages and tables of data, methodically reviewing the data.
‘Vaccines are the most effective way to prevent infectious diseases. They save millions of lives worldwide.’
During a round of interviews this morning, Mr Hancock said: ‘The NHS stands ready to start vaccinating early next week. The UK is the first country in the world to have a clinically approved vaccine for supply.’
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